Nemo is required in a subset of photoreceptors to regulate the speed of ommatidial rotation.

ABSTRACT: Both dramatic and subtle morphogenetic movements are of paramount importance in molding cells and tissues into functional form. Cells move either independently or as populations and the distance traversed by cells varies greatly, but in all cases, the output is common: to organize cells into or within organs and epithelia. In the developing Drosophila eye, a highly specialized, 90 degrees rotational movement of subsets of cells imposes order by polarizing the retinal epithelium across its dorsoventral axis. This process was proposed to take place in two 45 degrees steps, with the second under control of the gene nemo (nmo), a serine/threonine kinase. While our analysis confirms that these subsets of cells, the ommatidial precursors, do stall at 45 degrees , we demonstrate that nmo is also

SUBMITTER: Fiehler RW 

PROVIDER: S-EPMC2717089 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature