Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.

ABSTRACT:

Background

Some TGFB1 and VEGF polymorphisms are believed to be functional. Given that these genes are involved in tumor growth and progression including angiogenesis, dissemination, and invasiveness, we hypothesized that these polymorphisms would be associated with survival in patients with gastric cancer.

Methods

We genotyped TGFB1 -509 C>T, +1869 T>C, and +915 G>C and VEGF -1498T>C, -634G>C, and +936C>T in 167 patients with gastric cancer. Using the Kaplan and Meier method, log-rank tests, and Cox proportional hazard models, we evaluated associations among TGFB1 and VEGF variants with overall, 1-year, and 2-year survival rates.

Results

Although there were no significant differences in overall survival rates among all polymorphisms tested, patients with TGFB1+915CG

SUBMITTER: Guan X 

PROVIDER: S-EPMC2717936 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature