Extracellular space attenuates the effect of gap junctional remodeling on wave propagation: a computational study.

ABSTRACT:

Unlabelled

Ionic channels and gap junctions are remodeled in cells from the 5-day epicardial border zone (EBZ) of the healing canine infarct. The main objective of the study was to determine the effect of gap junctional conductance (Gj) remodeling and Cx43 redistribution to the lateral membrane on conduction velocity (theta) and anisotropic ratio, and how gap junctional remodeling is modulated by the extracellular space. We first implemented subcellular monodomain and two-domain computer models of normal epicardium (NZ) to understand how extracellular space modulates the relationship between Gj and theta in NZ. We found that the extracellular space flattens the Gj-theta relationship, thus theta becomes less sensitive to changes in Gj. We then investigated the functional consequence

SUBMITTER: Cabo C 

PROVIDER: S-EPMC2718274 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature