High-resolution computed tomography imaging of airway disease in infants with cystic fibrosis.

ABSTRACT:

Rationale

The development of early lung disease in patients with cystic fibrosis (CF) remains poorly defined.

Objective

Determine whether asymptomatic infants with CF have evidence for changes in airway structure when assessed by high-resolution computed tomography, and whether airway structure correlates with airway function in this age group.

Methods

Thirteen infants with CF (8-33 mo) and 13 control infants (7-25 mo) were evaluated. Airway wall and lumen areas were measured from three 1-mm-thick cross-sectional images obtained from upper, middle, and lower lobes during a respiratory pause with the lungs inflated to an airway pressure of 20 cm H2O. Lung tissue density was measured from images obtained during a respiratory pause at FRC. Forced expiratory flows were me

SUBMITTER: Martinez TM 

PROVIDER: S-EPMC2718397 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature