Investigative bronchoprovocation and bronchoscopy in airway diseases.

ABSTRACT:

Rationale

Basic and clinical research strategies used for many lung diseases have depended on volunteer subjects undergoing bronchoscopy to establish access to the airways to collect biological specimens and tissue, perhaps with added bronchoprovocation in asthma syndromes. These procedures have yielded a wealth of important scientific information. Since the last critical review more than a decade ago, some of the techniques and applications have changed, and untoward events have occurred, raising safety concerns and increasing institutional review scrutiny.

Objectives and methods

To reappraise these investigational methods in the context of current knowledge, the National Heart, Lung, and Blood Institute and the National Institute of Allergy and Infectious Diseases of the N

SUBMITTER: Busse WW 

PROVIDER: S-EPMC2718402 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature