Derivation and validation of a prognostic model for pulmonary embolism.

ABSTRACT:

Rationale

An objective and simple prognostic model for patients with pulmonary embolism could be helpful in guiding initial intensity of treatment.

Objectives

To develop a clinical prediction rule that accurately classifies patients with pulmonary embolism into categories of increasing risk of mortality and other adverse medical outcomes.

Methods

We randomly allocated 15,531 inpatient discharges with pulmonary embolism from 186 Pennsylvania hospitals to derivation (67%) and internal validation (33%) samples. We derived our prediction rule using logistic regression with 30-day mortality as the primary outcome, and patient demographic and clinical data routinely available at presentation as potential predictor variables. We externally validated the rule in 221 inpatient

SUBMITTER: Aujesky D 

PROVIDER: S-EPMC2718410 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature