Preinfection systemic inflammatory markers and risk of hospitalization due to pneumonia.

ABSTRACT:

Rationale

Elevated proinflammatory cytokines are associated with severity of pneumonia, but the role of preinfection cytokine levels in the predisposition to pneumonia in humans is less clear.

Objective

To ascertain role of preinfection inflammatory markers on susceptibility to community-acquired pneumonia (CAP).

Methods

Longitudinal analysis over 6.5 yr of a cohort that consisted of 70- to 79-yr-old well-functioning elderly individuals.

Measurements

Association between preinfection tumor necrosis factor (TNF), interleukin 6 (IL-6), and C-reactive protein (CRP) levels and CAP requiring hospitalization.

Results

Of the 3,075 participants, 161 (5.2%) developed at least one episode of CAP requiring hospitalization over a median duration of 3.3 yr. The highes

SUBMITTER: Yende S 

PROVIDER: S-EPMC2718438 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature