Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.

ABSTRACT:

Rationale

Recent genetic studies have implicated integrins in asthma and atopy susceptibility. We therefore evaluated the integrin-beta3 gene (ITGB3), an integrin gene within an asthma linkage peak on chromosome 17, as a candidate for susceptibility to asthma- and atopy-related phenotypes.

Methods and measurements

We genotyped and performed association tests on 19 single nucleotide polymorphisms in ITGB3 in the Hutterites, a founder population, and in three outbred replication populations.

Main results

Variation in ITGB3 was strongly associated with susceptibility to bronchial hyperresponsiveness and protection from allergic sensitization to mold allergens in this population. Three independent case-control populations representing Caucasians and African Americans were

SUBMITTER: Weiss LA 

PROVIDER: S-EPMC2718448 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature