TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences.

ABSTRACT:

Rationale

Exposure to second-hand smoke (SHS) has been associated with increased risk of respiratory illness in children including respiratory illness-related school absences. The role of genetic susceptibility in risk for adverse effects from SHS has not been extensively investigated in children.

Objective

To determine whether the tumor necrosis factor (TNF) G-308A genotype influences the risk for respiratory illness-related school absences associated with SHS exposure.

Methods

Incident school absences were collected, using an active surveillance system, between January and June 1996, as part of the Air Pollution and Absence Study, a prospective cohort study nested in the Children's Health Study. Buccal cells and absence reports were collected on 1,351 students from

SUBMITTER: Wenten M 

PROVIDER: S-EPMC2718456 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature