Effect of ductus ligation on cardiopulmonary function in premature baboons.

ABSTRACT:

Rationale

The role of the patent ductus arteriosus in the development of chronic lung disease in surfactant-treated premature newborns remains unclear.

Objective

To examine the effects of ductus ligation on cardiopulmonary function and lung histopathology in premature primates.

Methods

Baboons were delivered at 125 d, (term = 185 d) treated with surfactant, and ventilated for 14 d. Serial echocardiograms and pulmonary function tests were performed. Animals were randomized to ligation (n = 12) or no ligation (controls, n = 13) on Day 6 of life. Necropsy was performed on Day 14.

Results

Compared with nonligated control animals, ligated animals had lower pulmonary-to-systemic flow ratios, higher systemic blood pressures, and improved indices of right and left vent

SUBMITTER: McCurnin DC 

PROVIDER: S-EPMC2718457 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature