The effect of primary graft dysfunction on survival after lung transplantation.

ABSTRACT:

Rationale

Primary graft dysfunction is a severe acute lung injury syndrome after lung transplantation. Long-term outcomes of subjects with primary graft dysfunction have not been studied.

Objectives

We sought to test the relationship of primary graft dysfunction with both short- and long-term mortality using a large registry.

Methods

We used data collected on 5,262 patients in the United Network for Organ Sharing/International Society of Heart and Lung Transplantation registry between 1994 and 2000. We assessed outcomes in all subjects; to assess potential bias from the effects of early mortality, we also evaluated subjects who survived at least 1 year, using Cox proportional hazards models with time-varying covariates.

Main results

The overall incidence of pri

SUBMITTER: Christie JD 

PROVIDER: S-EPMC2718464 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature