Requirement for leukotriene B4 receptor 1 in allergen-induced airway hyperresponsiveness.

ABSTRACT:

Rationale

Leukotriene B4 (LTB4) is a rapidly synthesized, early leukocyte chemoattractant that signals via its cell surface receptor, leukotriene B4 receptor 1 (BLT1), to attract and activate leukocytes during inflammation. A role for the LTB4-BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation is not well defined.

Objectives

To define the role of the LTB4 receptor (BLT1) in the development of airway inflammation and altered airway function.

Methods

BLT1-deficient (BLT1 -/-) mice and wild-type mice were sensitized to ovalbumin by intraperitoneal injection and then challenged with ovalbumin via the airways. Airway responsiveness to inhaled methacholine, bronchoalveolar lavage fluid cell composition and cytokine levels, and lung inflammation and

SUBMITTER: Miyahara N 

PROVIDER: S-EPMC2718465 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature