Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma.

ABSTRACT:

Rationale

Increased oxidative stress and decreased superoxide dismutase (SOD) activity in the asthmatic airway are correlated to airflow limitation and hyperreactivity. We hypothesized that asthmatic individuals with higher levels of oxidative stress may have greater loss of SOD activity, which would be reflected systemically in loss of circulating SOD activity and clinically by development of severe asthma and/or worsening airflow limitation.

Methods

To investigate this, serum SOD activity and proteins, the glutathione peroxidase/glutathione antioxidant system, and oxidatively modified amino acids were measured in subjects with asthma and healthy control subjects.

Results

SOD activity, but not Mn-SOD or Cu,Zn-SOD protein, was lower in asthmatic serum as compared with

SUBMITTER: Comhair SA 

PROVIDER: S-EPMC2718470 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature