5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury.

ABSTRACT:

Rationale

Mechanical ventilation with high VT (HVT) progressively leads to lung injury and decreased efficiency of gas exchange. Hypoxic pulmonary vasoconstriction (HPV) directs blood flow to well-ventilated lung regions, preserving systemic oxygenation during pulmonary injury. Recent experimental studies have revealed an important role for leukotriene (LT) biosynthesis by 5-lipoxygenase (5LO) in the impairment of HPV by endotoxin.

Objectives

To investigate whether or not impairment of HPV contributes to the hypoxemia associated with HVT and to evaluate the role of LTs in ventilator-induced lung injury.

Methods

We studied wild-type and 5LO-deficient mice ventilated for up to 10 hours with low VT (LVT) or HVT.

Results

In wild-type mice, HVT, but not LVT, increas

SUBMITTER: Caironi P 

PROVIDER: S-EPMC2718472 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature