Tandem and cryptic amino acid repeats accumulate in disordered regions of proteins.

ABSTRACT:

Background

Amino acid repeats (AARs) are common features of protein sequences. They often evolve rapidly and are involved in a number of human diseases. They also show significant associations with particular Gene Ontology (GO) functional categories, particularly transcription, suggesting they play some role in protein function. It has been suggested recently that AARs play a significant role in the evolution of intrinsically unstructured regions (IURs) of proteins. We investigate the relationship between AAR frequency and evolution and their localization within proteins based on a set of 5,815 orthologous proteins from four mammalian (human, chimpanzee, mouse and rat) and a bird (chicken) genome. We consider two classes of AAR (tandem repeats and cryptic repeats: regions of protei

SUBMITTER: Simon M 

PROVIDER: S-EPMC2718493 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature