Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data.

ABSTRACT:

Background

Disordered proteins need to be expressed to carry out specified functions; however, their accumulation in the cell can potentially cause major problems through protein misfolding and aggregation. Gene expression levels, mRNA decay rates, microRNA (miRNA) targeting and ubiquitination have critical roles in the degradation and disposal of human proteins and transcripts. Here, we describe a study examining these features to gain insights into the regulation of disordered proteins.

Results

In comparison with ordered proteins, disordered proteins have a greater proportion of predicted ubiquitination sites. The transcripts encoding disordered proteins also have higher proportions of predicted miRNA target sites and higher mRNA decay rates, both of which are indicative o

SUBMITTER: Edwards YJ 

PROVIDER: S-EPMC2718516 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature