Lung adenocarcinoma global profiling identifies type II transforming growth factor-beta receptor as a repressor of invasiveness.

ABSTRACT:

Rationale

Lung adenocarcinoma histology and clinical outcome are heterogeneous and associated with tumor invasiveness.

Objectives

We hypothesized that invasiveness is associated with a distinct molecular signature and that genes differentially expressed in tumor or adjacent stroma will identify cell surface signal transduction and matrix remodeling pathways associated with the acquisition of invasiveness in lung adenocarcinoma.

Main results

Microarray analysis of microdissected noninvasive bronchioloalveolar carcinoma (BAC) and invasive adenocarcinoma and adenocarcinoma-mixed type with BAC features identified transcriptional profiles of lung adenocarcinoma invasiveness. Among the signature set that was lower in adenocarcinoma-mixed compared with BAC was the type II tr

SUBMITTER: Borczuk AC 

PROVIDER: S-EPMC2718552 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature