Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer.

ABSTRACT:

Context

Screening ultrasound may depict small, node-negative breast cancers not seen on mammography.

Objective

To compare the diagnostic yield, defined as the proportion of women with positive screen test results and positive reference standard, and performance of screening with ultrasound plus mammography vs mammography alone in women at elevated risk of breast cancer.

Design, setting, and participants

From April 2004 to February 2006, 2809 women, with at least heterogeneously dense breast tissue in at least 1 quadrant, were recruited from 21 sites to undergo mammographic and physician-performed ultrasonographic examinations in randomized order by a radiologist masked to the other examination results. Reference standard was defined as a combination of pathology and 1

SUBMITTER: Berg WA 

PROVIDER: S-EPMC2718688 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature