Low expression of a few genes indicates good prognosis in estrogen receptor positive breast cancer.

ABSTRACT:

Background

Many breast cancer patients remain free of distant metastasis even without adjuvant chemotherapy. While standard histopathological tests fail to identify these good prognosis patients with adequate precision, analyses of gene expression patterns in primary tumors have resulted in more successful diagnostic tests. These tests use continuous measurements of the mRNA concentrations of numerous genes to determine a risk of metastasis in lymph node negative breast cancer patients with other clinical traits.

Methods

A survival model is constructed from genes that are both connected with relapse and have expression patterns that define distinct subtypes, suggestive of different cellular states. This in silico study uses publicly available microarray databases generated w

SUBMITTER: Buechler S 

PROVIDER: S-EPMC2718903 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature