Disease associations with monoclonal gammopathy of undetermined significance: a population-based study of 17,398 patients.

ABSTRACT:

Objective

To systematically study the association of monoclonal gammopathy of undetermined significance (MGUS) with all diseases in a population-based cohort of 17,398 patients, all of whom were uniformly tested for the presence or absence of MGUS.

Patients and methods

Serum samples were obtained from 77% (21,463) of the 28,038 enumerated residents in Olmsted County, Minnesota. Informed consent was obtained from patients to study 17,398 samples. Among 17,398 samples tested, 605 cases of MGUS and 16,793 negative controls were identified. The computerized Mayo Medical Index was used to obtain information on all diagnoses entered between January 1, 1975, and May 31, 2006, for a total of 422,663 person-years of observations. To identify and confirm previously reported associatio

SUBMITTER: Bida JP 

PROVIDER: S-EPMC2719521 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature