Three different Plasmodium species show similar patterns of clinical tolerance of malaria infection.

ABSTRACT:

Background

In areas where malaria endemicity is high, many people harbour blood stage parasites without acute febrile illness, complicating the estimation of disease burden from infection data. For Plasmodium falciparum the density of parasitaemia that can be tolerated is low in the youngest children, but reaches a maximum in the age groups at highest risk of infection. There is little data on the age dependence of tolerance in other species of human malaria.

Methods

Parasite densities measured in 24,386 presumptive malaria cases at two local health centres in the Wosera area of Papua New Guinea were compared with the distributions of parasite densities recorded in community surveys in the same area. We then analyse the proportions of cases attributable to each of Plasmodium

SUBMITTER: Muller I 

PROVIDER: S-EPMC2719654 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature