Temporal stability of naturally acquired immunity to Merozoite Surface Protein-1 in Kenyan adults.

ABSTRACT:

Background

Naturally acquired immunity to blood-stage Plasmodium falciparum infection develops with age and after repeated infections. In order to identify immune surrogates that can inform vaccine trials conducted in malaria endemic populations and to better understand the basis of naturally acquired immunity it is important to appreciate the temporal stability of cellular and humoral immune responses to malaria antigens.

Methods

Blood samples from 16 adults living in a malaria holoendemic region of western Kenya were obtained at six time points over the course of 9 months. T cell immunity to the 42 kDa C-terminal fragment of Merozoite Surface Protein-1 (MSP-1(42)) was determined by IFN-gamma ELISPOT. Antibodies to the 42 kDa and 19 kDa C-terminal fragments of MSP-1 were de

SUBMITTER: Dent AE 

PROVIDER: S-EPMC2719655 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature