Predicting protein-protein interactions in Arabidopsis thaliana through integration of orthology, gene ontology and co-expression.

ABSTRACT:

Background

Large-scale identification of the interrelationships between different components of the cell, such as the interactions between proteins, has recently gained great interest. However, unraveling large-scale protein-protein interaction maps is laborious and expensive. Moreover, assessing the reliability of the interactions can be cumbersome.

Results

In this study, we have developed a computational method that exploits the existing knowledge on protein-protein interactions in diverse species through orthologous relations on the one hand, and functional association data on the other hand to predict and filter protein-protein interactions in Arabidopsis thaliana. A highly reliable set of protein-protein interactions is predicted through this integrative approach making

SUBMITTER: De Bodt S 

PROVIDER: S-EPMC2719670 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature