MHC-linked and un-linked class I genes in the wallaby.

ABSTRACT:

Background

MHC class I antigens are encoded by a rapidly evolving gene family comprising classical and non-classical genes that are found in all vertebrates and involved in diverse immune functions. However, there is a fundamental difference between the organization of class I genes in mammals and non-mammals. Non-mammals have a single classical gene responsible for antigen presentation, which is linked to the antigen processing genes, including TAP. This organization allows co-evolution of advantageous class Ia/TAP haplotypes. In contrast, mammals have multiple classical genes within the MHC, which are separated from the antigen processing genes by class III genes. It has been hypothesized that separation of classical class I genes from antigen processing genes in mammals allowed

SUBMITTER: Siddle HV 

PROVIDER: S-EPMC2719672 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature