Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease.

ABSTRACT:

Background

Single-nucleotide polymorphisms (SNPs) in 2 distinct regions of the gene for the sortilin-related receptor (SORL1) (bounded by consecutively numbered SNPs 8-10 and 22-25) were shown to be associated with Alzheimer disease (AD) in multiple ethnically diverse samples.

Objective

To test the hypothesis that SORL1 is associated with brain magnetic resonance imaging (MRI) measurements of atrophy and/or vascular disease.

Design, setting, and patients

We evaluated the association of 30 SNPs spanning SORL1 with MRI measures of general cerebral atrophy, hippocampal atrophy, white matter hyperintensities, and overall cerebrovascular disease in 44 African American and 182 white sibships from the MIRAGE Study. We performed single- and 3-SNP haplotype association analyse

SUBMITTER: T Cuenco K 

PROVIDER: S-EPMC2719762 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature