Ontology highlight
ABSTRACT:
SUBMITTER: Lee SJ
PROVIDER: S-EPMC2719773 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Lee Seok-Jin R SJ Escobedo-Lozoya Yasmin Y Szatmari Erzsebet M EM Yasuda Ryohei R
Nature 20090301 7236
Calcium/calmodulin-dependent kinase II (CaMKII) plays a central part in long-term potentiation (LTP), which underlies some forms of learning and memory. Here we monitored the spatiotemporal dynamics of CaMKII activation in individual dendritic spines during LTP using two-photon fluorescence lifetime imaging microscopy, in combination with two-photon glutamate uncaging. Induction of LTP and associated spine enlargement in single spines triggered transient ( approximately 1 min) CaMKII activation ...[more]