Cardiac hypertrophy involves both myocyte hypertrophy and hyperplasia in anemic zebrafish.

ABSTRACT:

Background

An adult zebrafish heart possesses a high capacity of regeneration. However, it has been unclear whether and how myocyte hyperplasia contributes to cardiac remodeling in response to biomechanical stress and whether myocyte hypertrophy exists in the zebrafish. To address these questions, we characterized the zebrafish mutant tr265/tr265, whose Band 3 mutation disrupts erythrocyte formation and results in anemia. Although Band 3 does not express and function in the heart, the chronic anemia imposes a sequential biomechanical stress towards the heart.

Methodology/principal findings

Hearts of the tr265/tr265 Danio rerio mutant become larger than those of the sibling by week 4 post fertilization and gradually exhibit characteristics of human cardiomyopathy, such as mus

SUBMITTER: Sun X 

PROVIDER: S-EPMC2719798 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature