Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression.

ABSTRACT:

Background

Most studies investigating the neurobiology of depression and suicide have focused on the serotonergic system. While it seems clear that serotonergic alterations play a role in the pathogenesis of these major public health problems, dysfunction in additional neurotransmitter systems and other molecular alterations may also be implicated. Microarray expression studies are excellent screening tools to generate hypotheses about additional molecular processes that may be at play. In this study we investigated brain regions that are known to be implicated in the neurobiology of suicide and major depression are likely to represent valid global molecular alterations.

Methodology/principal findings

We performed gene expression analysis using the HG-U133AB chipset in 17 co

SUBMITTER: Sequeira A 

PROVIDER: S-EPMC2719799 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature