Calpain-10 expression is elevated in pancreatic islets from patients with type 2 diabetes.

ABSTRACT:

Background

Calpain-10 was the first gene to be identified influencing the risk of type 2 diabetes (T2D) by positioning cloning. Studies in beta-cell lines and rodent islets suggest that calpain-10 may act as a regulator of insulin secretion. However, its role in human pancreatic islets remains unclear. The aim of this study was to examine if calpain-10 expression is altered in islets from patients with T2D and if the transcript level correlates with insulin release. We also tested if polymorphisms in the CAPN10 gene are associated with gene expression and insulin secretion in vitro.

Methodology/principal findings

Calpain-10 mRNA expression was analysed in human pancreatic islets from 34 non-diabetic and 10 T2D multi-organ donors. CAPN10 SNP-43 and SNP-44 were genotyped and r

SUBMITTER: Ling C 

PROVIDER: S-EPMC2719809 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature