Ontology highlight
ABSTRACT:
SUBMITTER: Ware CB
PROVIDER: S-EPMC2719860 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Cell stem cell 20090401 4
Recent evidence indicates that mouse and human embryonic stem cells (ESCs) are fixed at different developmental stages, with the former positioned earlier. We show that a narrow concentration of the naturally occurring short-chain fatty acid, sodium butyrate, supports the extensive self-renewal of mouse and human ESCs, while promoting their convergence toward an intermediate stem cell state. In response to butyrate, human ESCs regress to an earlier developmental stage characterized by a gene exp ...[more]