PathFinder: a static network analysis tool for pharmacological analysis of signal transduction pathways.

ABSTRACT: The study of signal transduction is becoming a de facto part of the analysis of gene expression and protein profiling techniques. Many online tools are used to cluster genes in various ways or to assign gene products to signal transduction pathways. Among these, pathFinder is a unique tool that can find signal transduction pathways between first, second, or nth messengers and their targets within the cell. pathFinder can identify qualitatively all possible signal transduction pathways connecting any starting component and target within a database of two-component pathways (directional dyads). One or more intermediate pathway components can be excluded to simulate the use of pharmacological inhibitors or genetic deletion (knockout). Missing elements in a pathway connecting the activator or

SUBMITTER: Samal BB 

PROVIDER: S-EPMC2719891 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature