The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice.

ABSTRACT: The mineralocorticoid aldosterone is a major regulator of sodium transport in target epithelia and contributes to the control of blood pressure and cardiac function. It specifically functions to increase renal absorption of sodium from tubular fluid via regulation of the alpha subunit of the epithelial sodium channel (alphaENaC). We previously used microarray technology to identify the immediate transcriptional targets of aldosterone in a mouse inner medullary collecting duct cell line and found that the transcript induced to the greatest extent was the circadian clock gene Period 1. Here, we investigated the role of Period 1 in mediating the downstream effects of aldosterone in renal cells. Aldosterone treatment stimulated expression of Period 1 (Per1) mRNA in renal collecting duct cell l

SUBMITTER: Gumz ML 

PROVIDER: S-EPMC2719945 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature