Plasma selenium, manganese superoxide dismutase, and intermediate- or high-risk prostate cancer.

ABSTRACT:

Purpose

In vitro, in vivo, and epidemiologic studies support a role for selenium in reducing the risk of prostate cancer. Our group previously demonstrated a strong interaction between plasma selenium and the manganese superoxide dismutase (SOD2) gene and incident prostate cancer risk. We now hypothesized that SOD2 modifies the association between selenium level and risk of aggressive prostate cancer at diagnosis.

Patients and methods

We assessed SOD2 variants and plasma selenium in 489 patients with localized/locally advanced prostate cancer from an ongoing retrospective cohort. Cross-sectional associations with aggressive prostate cancer (ie, stage T2b-3, prostate-specific antigen > 10 ng/mL, or biopsy Gleason score > or = 7) were evaluated using the chi(2) test, Cochran-A

SUBMITTER: Chan JM 

PROVIDER: S-EPMC2720077 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature