Cross-shift airway responses and long-term decline in FEV1 in cotton textile workers.

ABSTRACT:

Rationale

Acute airway response, measured as cross-shift change in FEV(1), to cotton dust may lead to subsequent chronic loss of lung function in exposed workers.

Objectives

To explore the association between the magnitude and frequency of cross-shift change and chronic loss of FEV(1).

Methods

Four hundred eight cotton workers and 417 silk workers from Shanghai textile mills were observed prospectively for 20 years, with cross-shift measurements at baseline and follow-up surveys at approximate 5-year intervals. To account for repeated measures of 5-year change, generalized estimating equations were used to estimate the relationship between the magnitude of cross-shift change in FEV(1) (DeltaFEV(1)) and subsequent 5-year annualized change. Linear regression models were

SUBMITTER: Wang X 

PROVIDER: S-EPMC2720104 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature