Association between pulmonary function and sputum biomarkers in cystic fibrosis.

ABSTRACT:

Rationale

Sputum biomarkers of infection and inflammation are noninvasive measures that enable quantification of the complex pathophysiology of cystic fibrosis (CF) lung disease. Validation of these biomarkers as correlates of disease severity is a key step for their application.

Objectives

We constructed a large database from four multicenter studies to quantify the strength of association between expectorated sputum biomarkers and FEV(1.)

Methods

FEV(1) (range, 25-120% predicted) and quantitative data on expectorated sputum biomarkers including free neutrophil elastase, IL-8, neutrophils, Pseudomonas aeruginosa, and Staphylococcus aureus were obtained from 269 participants (ages, 9-54 years) from 33 centers. Cross-sectional and longitudinal statistical analyses were

SUBMITTER: Mayer-Hamblett N 

PROVIDER: S-EPMC2720115 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature