Pulmonary nontuberculous mycobacterial disease: prospective study of a distinct preexisting syndrome.

ABSTRACT:

Rationale

Pulmonary nontuberculous mycobacterial (PNTM) disease is increasing, but predisposing features have been elusive.

Objectives

To prospectively determine the morphotype, immunophenotype, and cystic fibrosis transmembrane conductance regulator genotype in a large cohort with PNTM.

Methods

We prospectively enrolled 63 patients with PNTM infection, each of whom had computerized tomography, echocardiogram, pulmonary function, and flow cytometry of peripheral blood. In vitro cytokine production in response to mitogen, LPS, and cytokines was performed. Anthropometric measurements were compared with National Health and Nutrition Examination Survey (NHANES) age- and ethnicity-matched female control subjects extracted from the NHANES 2001-2002 dataset.

Measurements

SUBMITTER: Kim RD 

PROVIDER: S-EPMC2720143 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature