Automated identification of conserved synteny after whole-genome duplication.

ABSTRACT: An important objective for inferring the evolutionary history of gene families is the determination of orthologies and paralogies. Lineage-specific paralog loss following whole-genome duplication events can cause anciently related homologs to appear in some assays as orthologs. Conserved synteny-the tendency of neighboring genes to retain their relative positions and orders on chromosomes over evolutionary time-can help resolve such errors. Several previous studies examined genome-wide syntenic conservation to infer the contents of ancestral chromosomes and provided insights into the architecture of ancestral genomes, but did not provide methods or tools applicable to the study of the evolution of individual gene families. We developed an automated system to identify conserved syntenic reg

SUBMITTER: Catchen JM 

PROVIDER: S-EPMC2720179 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature