Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor.

ABSTRACT:

Background

The androgen receptor (AR) plays important roles in the development of male phenotype and in different human diseases including prostate cancers. The AR can act either as a promoter or a tumor suppressor depending on cell types. The AR proliferative response program has been well studied, but its prohibitive response program has not yet been thoroughly studied.

Methodology/principal findings

Previous studies found that PC3 cells expressing the wild-type AR inhibit growth and suppress invasion. We applied expression profiling to identify the response program of PC3 cells expressing the AR (PC3-AR) under different growth conditions (i.e. with or without androgens and at different concentration of androgens) and then applied the newly developed ChIP-seq technology to

SUBMITTER: Lin B 

PROVIDER: S-EPMC2720376 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature