Functional interpretation of APN receptor from M.sexta using a molecular model.

ABSTRACT: Insect pests are the major cause of damage to commercially important agricultural crops. The continuous application of synthetic pesticides resulted in severe insect resistance by plants. This causes irreversible damage to the environment. Bacillus thuringiensis (Bt) emerged as a valuable biological alternative in pest control. However, insect resistance against Bt has been reported in many cases. Insects develop resistance to insecticides through mechanisms that reduce the binding of toxins to gut receptors. Nonetheless, the molecular mechanism of insect resistance is not fully understood. Therefore, it is important to study the mechanism of toxin resistance by analyzing amino-peptidase-N (APN) receptor of the insect M. sexta. A homology model of APN was constructed using Insight II molec

SUBMITTER: Singh A 

PROVIDER: S-EPMC2720666 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature