Biomarkers for early detection of high risk cancers: from gliomas to nasopharyngeal carcinoma.

ABSTRACT: Nasopharyngeal carcinoma (NpC) is a malignant disease associated with Epstein-Barr virus infection, and often diagnosed at an advanced stage. This significantly curtails patient survival. We hypothesize that a panel of biomarkers can be assembled to assess NpC incidence, early detection, and tumor progression during therapeutic intervention. Our thesis rests on a model of successfully predicting high-risk gliomas by means of a carefully crafted panel of molecular mitotic biomarkers (i.e., securin, survivin and MCM2). The strategy we propose holds strong promise for prevention and cure of NpC. The approach we propose seeks to identify certain biomarkers from viral materials, patient tissues and assessment of related diseases, whose signatures, taken together, will be endowed with some degre

SUBMITTER: Oluwadara O 

PROVIDER: S-EPMC2720668 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature