Tissue biomarkers for prognosis in cutaneous melanoma: a systematic review and meta-analysis.

ABSTRACT: In the clinical management of early-stage cutaneous melanoma, it is critical to determine which patients are cured by surgery alone and which should be treated with adjuvant therapy. To assist in this decision, many groups have made an effort to use molecular information. However, although there are hundreds of studies that have sought to assess the potential prognostic value of molecular markers in predicting the course of cutaneous melanoma, at this time, no molecular method to improve risk stratification is part of recommended clinical practice. To help understand this disconnect, we conducted a systematic review and meta-analysis of the published literature that reported immunohistochemistry-based protein biomarkers of melanoma outcome. Three parallel search strategies were applied to

SUBMITTER: Gould Rothberg BE 

PROVIDER: S-EPMC2720709 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature