Model-based analysis of interferon-beta induced signaling pathway.

ABSTRACT:

Motivation

Interferon-beta induced JAK-STAT signaling pathways contribute to mucosal immune recognition and an anti-viral state. Though the main molecular mechanisms constituting these pathways are known, neither the detailed structure of the regulatory network, nor its dynamics has yet been investigated. The objective of this work is to build a mathematical model for the pathway that would serve two purposes: (1) to reproduce experimental results in simulation of both early and late response to Interferon-beta stimulation and (2) to explain experimental phenomena generating new hypotheses about regulatory mechanisms that cannot yet be tested experimentally.

Results

Experimentally determined time dependent changes in the major components of this pathway were used to build a

SUBMITTER: Smieja J 

PROVIDER: S-EPMC2720726 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature