MPI-LIT: a literature-curated dataset of microbial binary protein--protein interactions.

ABSTRACT:

Unlabelled

Prokaryotic protein-protein interactions are underrepresented in currently available databases. Here, we describe a 'gold standard' dataset (MPI-LIT) focusing on microbial binary protein-protein interactions and associated experimental evidence that we have manually curated from 813 abstracts and full texts that were selected from an initial set of 36 852 abstracts. The MPI-LIT dataset comprises 1237 experimental descriptions that describe a non-redundant set of 746 interactions of which 659 (88%) are not reported in public databases. To estimate the curation quality, we compared our dataset with a union of microbial interaction data from IntAct, DIP, BIND and MINT. Among common abstracts, we achieve a sensitivity of up to 66% for interactions and 75% for experimental me

SUBMITTER: Rajagopala SV 

PROVIDER: S-EPMC2720748 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature