Comparison of statistical methods for estimating genetic admixture in a lung cancer study of African Americans and Latinos.

ABSTRACT: A variety of methods are available for estimating genetic admixture proportions in populations; however, few investigators have conducted detailed comparisons using empirical data. The authors characterized admixture proportions among self-identified African Americans (n = 535) and Latinos (n = 412) living in the San Francisco Bay Area who participated in a lung cancer case-control study (1998-2003). Individual estimates of genetic ancestry based on 184 informative markers were obtained from a Bayesian approach and 2 maximum likelihood approaches and were compared using descriptive statistics, Pearson correlation coefficients, and Bland-Altman plots. Case-control differences in individual admixture proportions were assessed using 2-sample t tests and logistic regression analysis. Results i

SUBMITTER: Aldrich MC 

PROVIDER: S-EPMC2720774 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature