Association study between vitamin D receptor gene polymorphisms and asthma in the Chinese Han population: a case-control study.

ABSTRACT:

Background

Modulation of the immune system is one of the principal roles of Vitamin D, for which the effects are exerted via the vitamin D receptor (VDR). Importantly, variants in the VDR gene have been susceptible in the past to raise the risk of asthma in several populations. These effects of VDR allelic markers remain speculative in the Chinese Han population.

Results

A case-control study of 1090 individuals including 567 asthmatic patients was realized on five SNPs within the VDR gene. Only rs7975232 (ApaI) marker showed a significant association with asthma (P = 0.009). Haplotype analysis of the five VDR polymorphisms showed a significant association with asthma (global-p value = 0.012).

Conclusion

Although the susceptibility of VDR gene variants with asthma coul

SUBMITTER: Saadi A 

PROVIDER: S-EPMC2720948 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature