Differential expression of Aedes aegypti salivary transcriptome upon blood feeding.

ABSTRACT: Saliva of Aedes aegypti contains a complex array of proteins essential for both blood feeding and pathogen transmission. A large numbers of those proteins are classified as unknown in regard to their function(s). Understanding the dynamic interactions at the mosquito-host interface can be achieved in part by characterizing mosquito salivary gland gene expression relative to blood feeding. Towards this end, we developed an oligonucleotide microarray representing 463 transcripts to determine differential regulation of salivary gland genes. This microarray was used to investigate the temporal gene expression pattern of Ae. aegypti salivary gland transcriptome at different times post-blood feeding. Expression of the majority of salivary gland genes (77-87%) did not change significantly as a re

SUBMITTER: Thangamani S 

PROVIDER: S-EPMC2720950 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature