Identification of pediatric septic shock subclasses based on genome-wide expression profiling.

ABSTRACT:

Background

Septic shock is a heterogeneous syndrome within which probably exist several biological subclasses. Discovery and identification of septic shock subclasses could provide the foundation for the design of more specifically targeted therapies. Herein we tested the hypothesis that pediatric septic shock subclasses can be discovered through genome-wide expression profiling.

Methods

Genome-wide expression profiling was conducted using whole blood-derived RNA from 98 children with septic shock, followed by a series of bioinformatic approaches targeted at subclass discovery and characterization.

Results

Three putative subclasses (subclasses A, B, and C) were initially identified based on an empiric, discovery-oriented expression filter and unsupervised hierarchical

SUBMITTER: Wong HR 

PROVIDER: S-EPMC2720987 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature