Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis.

ABSTRACT:

Background

The association between hepatitis B virus (HBV) mutations and hepatocarcinogenesis remains controversial because of conflicting data in the literature. We conducted a meta-analysis of case-control and cohort studies to examine HBV PreS, enhancer II (EnhII), basal core promoter (BCP), and precore mutations in relation to the risk of hepatocellular carcinoma (HCC).

Methods

We searched databases for studies of these associations that were published in English or Chinese up to August 31, 2008. HBV mutation-specific odds ratios and relative risks were pooled by use of a random-effects model and stratified by potential confounders. All statistical tests were two-sided.

Results

Of the 43 studies included in this meta-analysis, 40 used a case-control design. The 43

SUBMITTER: Liu S 

PROVIDER: S-EPMC2720989 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature