Glycogen storage and muscle glucose transporters (GLUT-4) of mice selectively bred for high voluntary wheel running.

ABSTRACT: To examine the evolution of endurance-exercise behaviour, we have selectively bred four replicate lines of laboratory mice (Mus domesticus) for high voluntary wheel running (;high runner' or HR lines), while also maintaining four non-selected control (C) lines. By generation 16, HR mice ran approximately 2.7-fold more than C mice, mainly by running faster (especially in females), a differential maintained through subsequent generations, suggesting an evolutionary limit of unknown origin. We hypothesized that HR mice would have higher glycogen levels before nightly running, show greater depletion of those depots during their more intense wheel running, and have increased glycogen synthase activity and GLUT-4 protein in skeletal muscle. We sampled females from generation 35 at three times (p

SUBMITTER: Gomes FR 

PROVIDER: S-EPMC2721000 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature