Variation in bone morphogenetic protein 15 is not associated with spontaneous human dizygotic twinning.

ABSTRACT:

Background

Spontaneous dizygotic (DZ) twinning in humans is under genetic control. In sheep, heterozygous loss of function mutations in bone morphogenetic protein 15 (BMP15) increase ovulation and hence twinning rates.

Methods

To investigate the role of BMP15 in human twinning, we typed 14 common variants, 4 rare novel variants initially detected by sequencing 279 mothers of DZ twins (MODZT) and 17 variants previously associated with premature ovarian failure (POF) in 933 DZ twinning families. We also typed five additional POF associated GDF9 variants.

Results

There was some evidence for association between DZ twinning and a common intronic BMP15 variant (rs3897937), but this was not significant after correction for multiple testing. Three of the four novel variants (

SUBMITTER: Zhao ZZ 

PROVIDER: S-EPMC2721723 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature